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Cleaved-Caspase-3 p12 (D175) rabbit pAb
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ES1001
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Cleaved-Caspase-3 p12 (D175) rabbit pAb
反应性: Human;Rat;Mouse;
别名: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
宿主: Rabbit
稀释比: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
免疫原: The antiserum was produced against synthesized peptide derived from human Caspase 3. AA range:157-206
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 12 35kD
基因ID: 836
蛋白序列: P42574
细胞定位: Cytoplasm.
研究背景: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],
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