WB 1:500-2,000 IP 1:200 IF 1:100-200 IHC 1:200-500
免疫原:
Recombinant Protein
储存条件:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
克隆性:
Monoclonal
抗体亚型:
IgG1
浓度:
1mg/mL
实测条带:
65kDa
基因ID:
5970
蛋白序列:
Q04206
细胞定位:
Cytoplasm, Nucleus
研究背景:
NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.