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Calreticulin Rabbit pAb
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EA366
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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产品名称: Calreticulin Rabbit pAb
反应性: Human, Mouse, Rat
别名: CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA
宿主: Rabbit
稀释比: WB 1:500-1,000
免疫原: Recombinant Protein
储存条件: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1mg/mL
实测条带: 55kDa
基因ID: 811
蛋白序列: P27797
细胞定位: Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted
研究背景: Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .
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