产品中心

MEK4 (F194)Rabbit pAb
一键复制产品信息
EA362
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
下载说明 ①

Overview

产品名称: MEK4 (F194)Rabbit pAb
反应性: Human, Mouse, Rat
别名: JNK activating kinase 1, JNKK, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MAPKK4, MKK4, PRKMK4, SAPK/ERK kinase 1, SEK1, SERK1
宿主: Rabbit
稀释比: WB 1:1,000-2,000
免疫原: Recombinant Protein
储存条件: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1mg/mL
实测条带: 44kDa
基因ID: 6416
蛋白序列: P45985
细胞定位: Cytoplasm, Nucleus
研究背景: SAPK/Erk kinase (SEK1), also known as MEK4 or MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction .
关闭

在线咨询

Online consultation

  • 在线咨询
  • 技术支持

关注微信公众号

微信扫一扫立即咨询

微信电脑端咨询

微信扫一扫立即咨询

微信电脑端咨询
关闭