NFκB-p105/p50 (phospho Ser337) rabbit pAb-科鹿（武汉）生物科技有限责任公司

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NFκB-p105/p50 (phospho Ser337) rabbit pAb

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ES1466

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

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Overview

Product name:	NFκB-p105/p50 (phospho Ser337) rabbit pAb
Reactivity:	Human;Mouse
Alternative Names:	NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Source:	Rabbit
Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen:	Synthesized phospho-peptide around the phosphorylation site of human NFκB-p105/p50 (phospho Ser337)
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	105+50kD
GeneID:	4790
Human Swiss-Prot No:	P19838
Cellular localization:	Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Background:	nuclear factor kappa B subunit 1(NFKB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof

Western Blot analysis of various cells using Phospho-NFκB-p105/p50 (S337) Polyclonal Antibody diluted at 1:500
Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absor
Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absor
Immunohistochemistry analysis of paraffin-embedded human breast cancer, using NF-κB p105/p50 (Phospho-Ser337) Antibody. The picture on the right is blocked with the NF-κB p105/p50 (Phospho-Ser337) peptide.

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